Synthase Vs Synthetase enzyme
Synthase Vs Synthetase enzyme
| Synthase | Synthatase |
|---|
| Catalyzes the formation of new chemical bond between substrates without using ATP | Catalyze the formation of a new chemical bond between substrates using ATP |
| Does not require ATP for the bond formation reaction | Requires ATP as a source of energy for the bond formation |
| Can perform both ligation and cleavage reaction | Primarily involved in ligation reaction forming new chemical bond |
| Uses substrates directly to form the products | Requires ATP to activate one or more substrates, which are then used to form the products |
| Examples. Citrate synthase, acetyl CoA synthase | Examples. Aminoacyl-tRNA synthetase, glutamine synthetase |
Lyases Vs Ligase enzymes
| Lyases Enzyme | Ligases Enzyme |
|---|
| These enzymes catalyze bond breaking reaction | These enzymes catalyze bond formation reaction. |
| Acts on single substrate per reaction | Acts on two substrate or reactant per reaction |
| Elimination reactions are catalyzed by Lyases | Hydrolysis reaction are catalyzed by Ligases |
| Double bond is formed | Chemical bond is formed |
| In Glycolysis and Krebs cycle, lyases are used | Ligases are used in the DNA replication process |
| Lyases are also known as synthases | Ligases are also known as synthetases |
Phosphatase Vs Phosphorylase Enzyme
| Phosphatase | Phosphorylase |
|---|
| It catalyze the removal of phosphate group from molecules | It catalyze the addition of phosphate group to the molecules |
| It brings about dephosphorylation | It brings about phosphorylation |
| Substrates are various like proteins, nucleotides | substrate is Glucose-1-phosphate |
| Examples, protein phosphatase, acid phosphatase | example.. Glycogen phosphorylase |
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